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A total of 43 children with pulmonary hypertension received ambrisentan and tadalafil combination therapy. These children were started on ambrisentan and tadalafil due to Among participants with pulmonary arterial hypertension who had not received previous treatment, initial combination therapy with ambrisentan and tadalafil resulted in a significantly lower In the study, combination therapy with Letairis and tadalafil demonstrated superiority in reducing the risk of the composite primary endpoint versus monotherapy with Letairis or tadalafil. Overall, 20% of patients receiving combination therapy experienced a primary endpoint event compared to 35% and 30%, respectively, in patients receiving ambrisentan and tadalafil Background: In the randomized, double-blind, event-driven AMBITION study, initial combination therapy with ambrisentan and tadalafil was associated with a 50% reduction in risk of clinical failure (first occurrence of all-cause death, hospitalization for worsening pulmonary arterial hypertension [PAH], disease progression, or unsatisfactory long-term clinical response) vs pooled monotherapy. Background: In treatment-naive patients with pulmonary arterial hypertension, initial combination therapy with ambrisentan and tadalafil reduces the risk of clinical failure

Letairis tadalafil do more together than either alone See the study results for combination therapy. The AMBITION trial was designed and conducted by doctors to study the use of Letairis and tadalafil together to see if combining the two drugs is more effective than using either drug alone.